Serotonin plays an important role in the complex processes in the digestive tract as sleep.

We have found that patients suffering from irritable bowel syndrome with diarrhea a higher frequency of certain mutations show, explains Dr. Beate Niesler that investigates the genetic causes of complex diseases with her team in the Department of Human Molecular Genetics at the Heidelberg Institute for Human Genetics. These mutations seem to cause changes in the composition or the number of receptors on the cell surface. Signal transduction in the digestive tract may be disturbed and this may lead to overstimulation of the intestine. Resulting disturbances in fluid balance could explain the occurrence of diarrhea, says Johannes Kapeller, a doctoral student in the team..

Beate Niesler. The Heidelberg data could contribute to the development and prescription of specific medications for certain genetic mutations in patients.. Medication blocks serotonin receptorsThe serotonin receptor blockers alosetron the U.S., where the U.S., where it is effective in the treatment of women suffering from diarrhea – predominant IBS is used, but only with strict limitations due to its side are prescribed effects. Alosetron inhibits the serotonin receptors in the intestinal tract and thus slows the movement of the bowels.The phase III randomized German Breast Group study was carried out by the Managing Director of German Breast Group, Professor von Minckwitz of University Hospital for Women at Frankfurt, Germany. The results are set and at complement to 20th May issue the Journal of Clinical Oncology. ‘time is rewarding to see in that trastuzumab[Herceptin] considers but in women whose corrosive HER2-positive cancer advances,’said von Minckwitz.