One tumor capillaries.

One tumor capillaries, tiny blood vessels oxygen and nutrients oxygen and nutrients directly to cancer cells are irregularly shaped, excessively thin in some areas and forming thick, snarly clumps in others. These deformities turbulent, uneven blood flow, so that too much blood leads to a region of the tumor, and too little on the other. Moreover, the capillary endothelial cells of the inner surface of tumor capillaries, normally a smooth, tightly packed sheets, colleagues have demonstrated whereby vascular leakage. ‘These abnormal features tumor vessels impair delivery of circulating chemotherapeutic drugs to the actual site of the tumor,’says Kaustabh Ghosh, first author on the paper and a postdoctoral associate in the laboratory of Donald Ingber, paper ‘s senior author and interim co-director of the Vascular Biology program..

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