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WUSTL professor of biology in Arts & Sciences.

Up until this true point, researchers experienced presumed that nucleolar dominance was about turning on one group of parental ribosomal genes. In 1997, Pikaard and his co-workers produced headlines with an experiment which used chemical substances to inhibit the two-pronged method cells use to silence genes – – DNA methylation, which provides chemical substance flags to genes, and histone modification, which alters the proteins that become spools for DNA. The chemical substance inhibitors of silencing fired up the unexpressed group of parental genes previously, therefore demonstrated that the underlying system of nucleolar dominance turns genes off, not really on.