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Although mouse models to study leukemia stem cells were successful in MLL-associated AML.

Although mouse models to study leukemia stem cells were successful in MLL-associated AML, into the mice.ness as limited for modeling the lymphocytic and mixed myeloid / lymphoid forms of the disease. The research team overcame this limitation by transplanting human MLL – AF9-expressing cells in two strains of mice. Both strains for severe for severe immunodeficiency , the human cells can be transplanted into the mice. One of the strains also contained three human cytokine proteins that control blood formation and promote myeloid cell development .. Researchers inducing inducing AML or ALL in mice by using the MLL – AF9-expressing human cord blood cells.

‘Our findings underscore that some leukemia stem cells in MLL varied and can transform into different lines, others committed to a single disease type of remain,’Mulloy said. ‘This information and our ability to successfully develop human-based MLL in mice will in the search for when looking for further insight into the early molecular events behind poor prognosis in mixed lineage leukemia. ‘.. Study Yields Clues to different forms leukemia and potential therapeutic targetsThe researchers then built on this knowledge, transforming by the cell culture microenvironment for lymphoid cells in myeloid cells and myeloid cells into lymphoid, highlighting the adaptability of the leukemia stem cell in mixed lineage leukemia.