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Most cases of RTS caused by mutation of the CBP gene.

Genetic disorder that path at any of several points, the mice caused skeletal defects remember the seen in individuals with RTS develop. Whenof potential therapeutic interest, treatment mice destined to develop RTS-like skeletal defects when. In utero with molecules such as BMPs , which were known to stimulate bone growth, partially reversed their skeletal abnormalities at birth Glimcher and his colleagues therefore suggest that in utero supplementation with growth factors could have a new way to genetic diseases to treat characterized by skeletal defects..

Similar growth inhibition was observed after reduction of ATR expression in acute myeloid leukemia cells without p53 and expression of a constitutively active mutant form of Ras. These mouse data lead Brown and colleagues suggest that targeting ATR could provide benefits to patients with tumors with specific genetic mutations.. TITLE: Administration of BMP2 / 7 in utero partially Rubinstein-Taybi syndrome-like skeletal defects reverses induced by PDK1 or Cbp mutations in miceAUTHORS: Laurie H.